..In a small, randomized study of 37 cocaine-dependent adults, those treated with Champix (varenicline) experienced significantly lower levels of reward effect from cocaine compared to those being treated with placebo..

..Some of the concerns the author raises are the lack of FDA safety data regarding the liquid nicotine, and the little clinical data on the safety and efficacy of electronic cigarettes as part of a smoking cessation program..

A new study coming out of the Unites States is reporting  that there is a substantial increased risk of reported depression/suicidal behaviour associated with varenicline (Champix) than with other smoking cessation products.  The study looked at 3,249 reported cases of suicidal/self-injurious behaviour, 90% of which was associated with varenicine, 10% with bupropion, and 3% for  [...]

A new systematic review and meta-analysis published online in the Lancet has shown that women who smoke have a higher chance of developing coronary artery disease than men who smoke. Researchers asserted that women may extract more carcinogens and other toxic agents than men after smoking the same number of cigarettes. Except for those between the ages [...]

Toronto’s Centre for Addiction and Mental Health (CAMH) released study yesterday showing that people who 25 or more cigarettes a day had elevated levels of monoamine oxidase in their brains 8 hours after their last cigarette. The same chemical is elevated in the brains of those said to be clinically depressed. The study’s authors say that this [...]

Pfizer has put out a statement in response to the CMAJ varenicline article, asserting that the authors’ conclusions are misleading because they are based on a small number of cardiovascular events. Pfizer states that the study’s report of a 72% increase in adverse cardiovascular events among smokers using varenicline has been taken out of context. [...]